Stanley T. Crooke's Antisense Drug Technology: Principles, Strategies, and PDF

By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

widely revised and up-to-date, Antisense Drug expertise: ideas, options, and functions, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based remedies, and, specifically, antisense therapeutics and learn. examining classes realized from the scientific trials of first iteration medicines, the publication evaluates the know-how as an entire and provides new instructions and avenues of study and improvement.

Divided into 5 components, the e-book starts off with an intensive creation to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. best researchers show the fundamentals of oligonucleotide therapeutics partly via delineating medicinal chemistry, pharmacokinetics, and supply routes similar to liposomal formulations for nucleic acid delivery.  half 3 info hybridization dependent medications and considers the dramatic advances represented via 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical sessions of gear and mechanisms of motion are defined partially 4 with additional discussions on enhancing the second one iteration antisense medicines. the ultimate half delves deeply into healing purposes. Contributing authors study the opportunity of antisense medicinal drugs for the relief of cardiovascular illnesses, metabolic illnesses, inflammatory illnesses, melanoma, neurological issues, and immune modulation.

Presenting a hugely distinctive, lucid dialogue of the outstanding advances within the box, Antisense Drug know-how: ideas, suggestions, and functions, moment Edition presents the platform for researchers to proceed to aggressively pursue the good chance represented via this interesting technology.

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Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition by Stanley T. Crooke

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